Association Between Grade(B/C)of Stage III and IV Periodontitis and High Sensitivity C Reactive Protein Level in Serum and Oral Rinse Sample

NCT06997770 · tracked via the Priya Life Science India tracker

Sponsor

Postgraduate Institute of Dental Sciences Rohtak

Phase

Observational

Started

2025-06-25

Last updated

2025-05-30

Condition(s) studied

hsCRP

Study summary

According to 2017 World Workshop of Periodontology , the level of high sensitivity C reactive protein has been assumed to increase according to the grade of periodontitis, however, specific evidence regarding this is lacking at present. Hence, measuring high sensitivity C reactive protein in serum and oral rinse samples in systemically healthy individuals with periodontitis could be potentially useful in gaining insight on the systemic burden of periodontal disease.

Eligibility

Sex

ALL

Min age

18 Years

Max age

50 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Patients in the age group of (18-50 years) * Presence of ≥ 20 natural teeth * Ability and willingness to give written informed consent * Patients belonging to 3 groups -periodontally healthy, stage III and stage IV grade B periodontitis, and stage III and stage IV grade C periodontitis . Exclusion Criteria: * • Patients with chronic inflammatory disease such as nephrotic syndrome, chronic renal failure, significant cardiovascular disease, established type 1 or type 2 diabetes mellitus, or active cancer within the past 5 years * Smokers and alcoholics * Pregnant females * Presence of xerostomia * Patients undergoing radiotherapy * Having received professional periodontal treatment within the previous 6 months * Having received antibiotic medication 3 months prior to study * Periapical pathology or other oral inflammatory conditions * Cognitive disability (interfering with ability to give sample)

Primary outcome measure(s)

Evaluation of hscrp level in oral rinse samples and serum in 3 groups of systemically healthy individuals — 12-14 months
Evaluation of hsCRP level in oral rinse samples and serum in 3 groups of systemically healthy individuals (periodontally healthy, stage III and stage IV grade B generalized periodontitis, stage III and stage IV grade C generalized periodontitis)

Trial sites (1)

Facility	City	Region	Status
PGIDS	Rohtak	Haryana