Postoperative Radiotherapy in Breast Cancer- Concurrent or Sequential With Chemotherapy

Condition(s) studied

Investigational drug(s) / intervention(s)

Chemoradiation: This intervention will consist of getting chemotherapy followed by radiotherapy, i.e, in a sequential manner

Chemoradiation: This intervention will consist of getting chemotherapy and radiotherapy at the same time, i.e, in a concurrent manner.

Study summary

This clinical research aims to determine if concurrent chemotherapy and radiation therapy is more effective than sequential chemotherapy and radiation therapy for patients with stage IIB-III breast cancer. It seeks to answer the following key questions:

1. When compared to sequential treatment, does concurrent chemoradiotherapy increase disease-free survival?
2. What effects does concurrent treatment have on post-operative look, quality of life, and side effects including arm swelling (lymphoedema)?
3. What are each treatment approach's financial costs?

Researchers will compare the following to groups:

Arm A: Participants in the sequential treatment group will first undergo chemotherapy and then radiation.

and Arm B: Participants in the concurrent treatment group will undergo radiation therapy while undergoing chemotherapy.

Participants are going to:

1. Get the usual chemotherapy (taxanes and/or anthracyclines).
2. Receive radiation therapy for three to four weeks.
3. Have follow-up visits every 6months for 5years to check for cancer recurrence, side effects, and quality of life.

Eligibility

Primary outcome measure(s)

• Study the 3-year Disease Free Survival. — From enrollment to 3 years after treatment at six months intervals.

Trial sites (5)