PET/CT GUIDED BIOPSY VERSUS CT GUIDED BIOPSY IN EVALUATION OF SUSPECTED LUNG NEOPLASMS

NCT06923098 · tracked via the Priya Life Science India tracker

Sponsor

All India Institute of Medical Sciences, Bhubaneswar

Phase

Not applicable

Started

2023-07-01

Last updated

2025-04-11

Condition(s) studied

Lung Diseases

Investigational drug(s) / intervention(s)

PET-CT guided biopsyCT guided biopsy

PET-CT guided biopsy: PET-CT guided biopsy of lung lesions

CT guided biopsy: CT guided biopsy of lung lesions

Study summary

Percutaneous CT guided biopsy is a well-established, standard sampling technique for suspected neoplastic lesions located in peripheral region in lung parenchyma. Inconclusive results on CT guided biopsy is substantially higher in large lung lesions which are prone to cause peripheral pneumonia, atelectasis and even regional necrosis, which are hard to be distinguished from tumor on CT images.

Functional imaging guided biopsy like PET/CT guided biopsy identifies areas of highest concentration of neoplastic cells and provides accurate results. Only a few studies have been done regarding PET/CT guided biopsy and studies omparing PET/CT guided and CT guided percutaneous transthoracic lung biopsy are very few and this study would be a randomized trial comparing these diagnostic modalities in terms of diagnostic yield, diagnostic accuracy of sample and complications.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age above 18 years * INR \< 1.2 and platelet counts \> 80,000/mm3 * CT thorax with lung lesion more than 10 mm. * Accessible lesions for CT-guided biopsy. Exclusion Criteria: * Participants with pre-existing bleeding diathesis like hemophilia, coagulopathy defined by -INR ≥1.2 and Platelet counts ≤ 80,000/mm3 * Participants who refuse to provide consent * Signs of hypoperfusion like hypotension, cyanosis etc. * Presence of hypoxemia with SpO2 \< 94 %- measured in a pulse oximeter) * Pregnant/Lactating female subjects * Non-cooperative subjects * Lesions that are inaccessible (decision made on pre-biopsy planning) * Serum creatinine level more than 2mg/dl.

Primary outcome measure(s)

Inconclusive pathology findings — 1 month
Comparing the proportion of inconclusive pathology reports in both arms

Trial sites (1)

Facility	City	Region	Status
All India Institute of Medical Sciences, Bhubaneswar	Bhubaneswar	Odisha	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06923098 on ClinicalTrials.gov ↗ ← All trials in India