NMR Based Metabolomics Kinetics in ARDS Patients

NCT06036056 · tracked via the Priya Life Science India tracker

Sponsor

Sanjay Gandhi Postgraduate Institute of Medical Sciences

Phase

Observational

Started

2023-09-13

Last updated

2024-11-27

Condition(s) studied

ARDS

Study summary

Acute respiratory distress syndrome (ARDS) is a life-threatening condition requiring respiratory support to maintain oxygenation. Very few biomarkers about ARDS have been identified but none of them has a sufficient specificity or sensitivity to characterize by itself the severity of lung condition. Investigators hypothesize that there is considerable change occurring in metabolic profiles in mild, moderate, and severe ARDS in comparison to healthy cohort, which can be detectable through serum analysis using NMR based metabolomics study. This research would help to understand metabolomics kinetics during the ARDS disease progression. Overall, NMR-based metabolomics study would provide an insight into the mediators involved in pathogenesis and progression of ARDS.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Accepted

Inclusion Criteria: * Critically ill adult patients having mild ARDS with onset less than 72 hours Exclusion Criteria: * Age less than 18 years or more than 65 years * Expected survival \<72 hours * Refusal from family member

Primary outcome measure(s)

To identify the potential biomarkers in mild ARDS using NMR based metabolomics — Up to the 72 hours after the diagnosis of mild ARDS
NMR based metabolomics in the serum of patients with mild ARDS
To study the kinetics of NMR based metabolomics in mild ARDS and its association with progression of ARDS severity. — Three weeks after diagnosing mild ARDS or till ICU discharge (whichever comes first)
Changes in NMR based metabolomics in serum of patients with mild ARDS

Trial sites (1)

Facility	City	Region	Status
Centre of Biomedical Research	Lucknow	Uttar Pradesh	Recruiting