National Institute of Allergy and Infectious Diseases (NIAID)
Phase
Observational
Started
2021-06-01
Last updated
2025-12-18
Condition(s) studied
COVID-19
Study summary
This is a pilot, cross-sectional, sample collection study to characterize the immune response and intestinal microorganisms in people with and without COVID-19 antibodies and helminth infection.
Eligibility
Sex
ALL
Min age
5 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* Able to provide informed consent.
Exclusion Criteria:
* Poor venous access precluding venipuncture.
* History of any illness or condition which, in the investigator's judgment, may substantially increase the risk associated with the participant's participation in the protocol, or compromise the scientific objectives.
Participants may be co-enrolled in other studies; however study staff should be notified of co-enrollment.
Primary outcome measure(s)
Number of participants with helminth infections — Day 1 Measured by qPCR diagnostics of stool DNA extraction
Number of participants with SARS-CoV-2 antibodies — Day 1 Measured by real-time qPCR (quantitative polymerase chain reaction) assay
Number of participants with positive malaria test — Day 1 Measured by fingerprick blood samples
Average Differential blood count — Day 1 Measured from venipuncture blood samples
Average Hematocrit levels — Day 1 Measured from venipuncture blood samples
Number of participants with latent tuberculosis infection — Day 1 Measured by IFN-γ release assay
Number of participants with Wuchereria bancrofti infection — Day 1 Measured by enzyme-linked immunosorbent assay (ELISA)
Number of participants with Strongyloides stercoralis infection — Day 1 Measured by enzyme-linked immunosorbent assay (ELISA)
Number of participants with Ascaris infection — Day 1 Stool sample analysis DNA extraction for qPCR and 16S sequencing
Number of participants with hookworm infection — Day 1 Stool sample analysis DNA extraction for qPCR and 16S sequencing
Number of participants with Strongyloides infection — Day 1 Stool sample analysis using Baermann technique, DNA extraction for qPCR and 16S sequencing
Number of participants with Trichuris infection — Day 1 Stool sample analysis using DNA extraction for qPCR and 16S sequencing
Trial sites (1)
Facility
City
Region
Status
National Institute for Research in Tuberculosis - International Centers for Excellence in Research (NIRT-ICER)
Chennai
Tamil Nadu
More National Institute of Allergy and Infectious Diseases (NIAID) trials in India
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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