Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding

NCT04662918 · tracked via the Priya Life Science India tracker

Sponsor

Xingshun Qi

Phase

Observational

Started

2022-01-01

Last updated

2025-10-07

Condition(s) studied

GastroIntestinal Bleeding

Study summary

Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion. A novel model, CAGIB score, has been developed based on our Chinese multicenter retrospective study. Now, a prospective, international multicenter, observational study will be performed to further compare the performance of CAGIB versus Child-Pugh and MELD scores for evaluating the in-hospital mortality of patients with liver cirrhosis and acute gastrointestinal bleeding.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. Patients with liver cirrhosis; 2. Patients with acute gastrointestinal bleeding presenting with hematemesis, melena, and/or hematochezia; 3. Adults (age≥18 years old). Exclusion Criteria: 1. Components of Child-Pugh, MELD, and CAGIB scores are not available; 2. In-hospital outcomes are not evaluable.

Primary outcome measure(s)

Mortality — An average of 1-6 weeks, from admission to discharge
Death caused by any events during hospitalizations.

Trial sites (23)

Facility	City	Region	Status
The Wright Center for Graduate Medical Education, 501 S. Washington Avenue	Scranton	Pennsylvania	Not Yet Recruiting
São Paulo State University (UNESP), Botucatu Medical School	São Paulo	São Paulo	Recruiting
Beijing Youan Hospital, Capital Medical University	Beijing	Beijing Municipality	Recruiting
The Seventh Medical Center of Chinese PLA General Hospital	Beijing	Beijing Municipality	Not Yet Recruiting
First Affiliated Hospital of Fujian Medical University	Fuzhou	Fujian	Recruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology	Wuhan	Hubei	Recruiting
First Affiliated Hospital of Nanchang University	Nanchang	Jiangxi	Recruiting
The Six People's Hospital of Dalian	Dalian	Liaoning	Recruiting
Air Force Hospital of Northern Theater Command	Shenyang	Liaoning	Recruiting
General Hospital of Northern Theater Command	Shenyang	Liaoning	Recruiting
The First Hospital of China Medical University	Shenyang	Liaoning	Recruiting
The Six People's Hospital of Shenyang	Shenyang	Liaoning	Recruiting
Tangdu Hospital, Fourth Military Medical University,	Xi'an	Shaanxi	Recruiting
The First Affiliated Hospital of Xi'an Jiao Tong University	Xi'an	Shaanxi	Recruiting
The Second Affiliated Hospital of Xi'an Jiao Tong University	Xi'an	Shaanxi	Recruiting
Xi'an Central Hospital	Xi'an	Shaanxi	Recruiting
Shandong Provincial Hospital	Jinan	Shandong	Recruiting
Cathay General Hospital, Fu-Jen Catholic University School of Medicine	Taibei	Taiwan	Not Yet Recruiting
Charité University Medical Center	Berlin	State of Berlin	Recruiting
Ernakulam Medical Center	Kochi	Kochi	Not Yet Recruiting
Azienda di Rilievo Nazionale ad Alta Specializzazione Civico-Di Cristina-Benfratelli	Palermo	Palermo	Recruiting
National Autonomous University of Mexico	Mexico City	Mexico City	Recruiting
Bezmialem Vakif University	Istanbul	Istanbul	Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04662918 on ClinicalTrials.gov ↗ ← All trials in India