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Clinical trial register · European Union · CTIS

Clinical Trials in Spain

The most recently authorised trials on the EU Clinical Trials Information System (CTIS), the single register for every trial run under the EU Clinical Trials Regulation (536/2014). CTIS holds a far larger historical archive than any one list can usefully show — this register states both numbers rather than picking one.

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Source: EMA Clinical Trials Information System (CTIS). Showing the 2500 most recently authorised of 12445 total CTIS records — a stated recency window, not the full historical archive. Synced 20 Sep 2026, 03:17 UTC
2500
Shown in this register
most recently authorised
12,445
Total on CTIS
full historical archive
745
Phase III
within the shown window
Top member states
Spain 1023 France 890 Germany 861 Italy 742 Poland 581 Netherlands 524
Narrow the registerReset
Phase
Phase I 558 Phase I/II 214 Phase II 726 Phase III 745 Phase IV 257
Lead sponsor
AstraZeneca AB 60 Assistance Publique Hopitaux De Paris 49 Merck Sharp & Dohme LLC 48 Pfizer Inc. 45 Novo Nordisk A/S 42
Member state
Spain 1023 France 890 Germany 861 Italy 742 Poland 581 Netherlands 524 Belgium 426 Czechia 327
All 28 states
64 of 2500 shown studies
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Phase
Study
Lead sponsor
Area
Member states
Decision
Phase IV
Phase IV, randomized, open label, parallel groups clinical trial for evaluating the early Stop of antibiotic Treatment in high-risk febrile neutropenic Oncohaematological Paediatric patients (e-STOP 2)
2025-524264-38-00Infectious diseases
Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca
Not possible to specify
Spain
05/05/2026
Phase IV
Efficacy and Safety of Daridorexant in Patients with Major Depressive Disorder (MDD) and Insomnia: Double-blind, randomized, controlled trial
2025-524794-16-00Patients with major depressive episode and moderate to seve…
Fundacio Institut D'Investigacio Biomedica De Bellvitge IDIBELL
Mental Disorders
Spain
04/05/2026
Phase IV
Multicenter clinical trial on the effectiveness and safety of outpatient treatment of acute uncomplicated diverticulitis without antibiotics versus antibiotic treatment. ADIANA Trial.
2025-523121-17-00Diverticular disease of the intestine,
Fundacion Para La Formacion E Investigacion Sanitaria De La Region De Murcia
Digestive System Diseases
Spain
30/04/2026
Phase IV
Switching to Mesalazine Monotherapy vs Continuing Thiopurines in Older Patients with Ulcerative Colitis in Sustained Remission: A Multicenter Randomized Controlled Trial (IDEA).
2025-524675-23-00Ulcerative Colitis
Grupo Espanol De Trabajo En Enfermedad De Crohn y Colitis Ulcerosa
Digestive System Diseases
Spain
30/04/2026
Phase IV
A Study to Evaluate Mirikizumab Concentrations in Breast Milk Following Administration of Mirikizumab by Subcutaneous Injection in Lactating Participants Receiving Mirikizumab Therapeutically for an Approved Indication
2025-522362-78-00severely active ulcerative colitis (US) and CD (Crohn’s dis…
Eli Lilly & Co.
Immune System Diseases
Spain, Denmark, Germany, Italy, Poland
27/04/2026
Phase IV
Application of radiomics in molecular imaging (18F-FDG-PET/CT) for diagnosis and follow-up of cardiovascular device infections: PREDICT study
2025-524624-21-00Cardiovascular device infections
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Virus Diseases
Spain
07/04/2026
Phase IV
Combined impact of cardiovascular polypill treatment and a specific nurse education program on adherence to therapy in patients with ACS: a randomized study
2025-524751-32-00Acute coronary syndrome
Fundacion Epic
Cardiovascular Diseases
Spain
30/03/2026
Phase IV
TheRapeutic StrAtegies for Obstructive SleeP Apnea in Older Adults with OverweigHt or Obesity: A RandomizEd Clinical TriaL (RAPHAEL study)
2025-524819-37-00obstructive sleep apnea
Institut De Recerca Biomedica De Lleida Fundacio Dr. Pifarre
Respiratory Tract Diseases
Spain
30/03/2026
Phase IV
Dexamethasone for the treatment of traumatic brain injured patients with brain contusions and pericontusional edema: Study protocol for a prospective, randomized and double blind trial
2025-520887-17-00Post-traumatic brain contusion with edema
University Hospital Son Espases
Nervous System Diseases
Spain
26/03/2026
Phase IV
Randomized, multicenter, open-label clinical trial to evaluate the clinical and microbiological impact of methenamine hippurate as an alternative prophylaxis to antibiotics in the management of recurrent urinary tract infections in women
2025-523922-42-00recurrent urine infections
Consorci Mar Parc De Salut De Barcelona
Female Urogenital Diseases and Pregnancy Complications
Spain
25/03/2026
Phase IV
Use of half the iodinated contrast medium for monitoring thoracic neoplasms using spectral CT: Randomized, crossover, non-inferiority clinical trial
2025-524901-33-00Thoracic neoplasm
Fundacion De La Comunitat Valenciana Para La Gestion Del Instituto De Investigacion Sanitaria Y Biomedica De Alicante
Diagnosis
Spain
17/03/2026
Phase IV
Impact Of Upadacitinib On The Frequency Of Acute Recurrent Anterior Uveitis In Patients With Axial Spondyloarthritis (UP-FOR-U)
2025-522118-21-00Axial Spondyloarthritis, Acute Anterior Uveitis
Care Arthritis Ltd.
Eye Diseases
Spain, Poland, Netherlands, France, Bulgaria, Germany
13/03/2026
Phase IV
Botulinum toxin in open abdomen closure. A multicentric randomized controlled single-blind clinical trial to evaluate the efficacy of early administration of botulinum toxin for primary midline closure in patients with an open abdomen.
2025-522410-23-00open abdomen
Hospital Universitario La Paz
Not possible to specify
Spain
04/03/2026
Phase IV
Efficacy and tolerability of a simethicone-containing evacuating solution for colorectal cancer screening colonoscopy: a randomized parallel comparative trial. CLEAN+
2025-523748-11-00colorectal cancer early detection
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Digestive System Diseases
Spain
20/02/2026
Phase IV
Long-term Safety Outcomes in Patients Treated With Replimune Oncolytic Immunotherapy Products
2025-521621-33-00Hepatocellular Carcinoma, Melanoma, Metastatic Melanoma, Ad…
Replimune Group Inc.
Neoplasms
Germany, Greece, France, Poland, Spain
09/02/2026
Phase IV
Adductor canal and IPACK (infiltration between the popliteal artery and the capsule of the knee) blocks versus genicular nerves block for total knee arthroplasty: A randomized clinical trial
2025-523071-34-00Knee Osteoarthritis
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Musculoskeletal Diseases
Spain
06/02/2026
Phase IV
EFFICACY OF INFILTRATED MEPIVACAINE AS A LOCAL ANESTHETIC PRIOR TO ARTERIAL PUNCTURE: A RANDOMIZED CONTROLLED CLINICAL TRIAL
2025-522974-35-00Respiratory disease. Prescripcion o indicación de gasometrí…
University Of The Basque Country
Respiratory Tract Diseases
Spain
28/01/2026
Phase IV
International multicentre, open-label, phase IV clinical trial to evaluate the efficacy, safety and effect on quality of life of bilastine in children with allergic rhinoconjunctivitis
2024-519550-36-00Allergic rhinoconjunctivitis
Faes Farma S.A., A. Menarini Industrie Farmaceutiche Riunite S.r.l.
Immune System Diseases
Poland, Spain, Italy
19/01/2026
Phase IV
A multicenter randomized, controlled, single-blind, adaptive phase IV clinical trial to evaluate the efficiency and effectiveness of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT adaptive clinical trial.
2025-522967-13-00Depressive disorder
Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz
Mental Disorders
Spain
11/01/2026
Phase IV
Impact of EXercise on quality of life of early breast cancer patients on treatment with adjuvant Aromatase Inhibitors with or without CDK4/6 inhibitors. "The EX-AI study"
2025-522848-40-00Early Breast Cancer
Fundacion Grupo Espanol De Investigacion En Cancer De Mama
Neoplasms
Spain
29/12/2025
Phase IV
Insulin resistance in type 2 diabetes: evaluating the pathogenic mechanisms of insulin resistance in the myocardium and the effects of the treatments with GLP-1RA and SGLT2i
2025-523374-17-01Type 2 diabetes
Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca
Nutritional and Metabolic Diseases
Spain
23/12/2025
Phase IV
Phase IV, single-center, randomized, crossover clinical trial to validate the use of gadopiclenol versus gadobutrol in the evaluation of magnetic resonance imaging (MRI) diagnosis of perianal fistula associated with Crohn's disease
2025-523278-18-00Perianal fistula associated with Crohn's disease
Fundacio Hospital Universitari Vall D’Hebron Institut De Recerca
Diagnosis
Spain
18/12/2025
Phase IV
EFFICACY OF FARICIMAB IN PATIENTS WITH SUBRETINAL HYPERREFLECTIVE MATERIAL ASSOCIATED WITH TYPE 2 OR MIXED NEOVASCULAR MEMBRANES ASSESSED BY MULTIMODAL IMAGING
2025-522701-38-00SUBRETINAL HYPERREFLECTIVE MATERIAL
Asociacion Instituto De Investigacion Sanitaria Biobizkaia
Eye Diseases
Spain
15/12/2025
Phase IV
Evaluation of the persistency of the preoperative anxiolytic effect of music therapy vs midazolam: electroencephalographic and clinical analysis
2025-522575-29-00Preoperative anxiety
Consorci Mar Parc De Salut De Barcelona
Anesthesia and Analgesia
Spain
05/12/2025
Phase IV
Phase IV, open-label, randomized clinical trial on the effect of intravenous iron on quality of life in elderly patients with Acute Coronary Syndrome.
2025-522421-36-00Acute coronary syndrome
Instituto De Investigacion Sanitaria Fundacion Para La Investigacion Del Hospital Clinico De Valencia-INCLIVA
Cardiovascular Diseases
Spain
03/12/2025
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Priya Life Science (2026). EU Clinical Trials Register (CTIS), filtered. Derived from the EMA Clinical Trials Information System. Retrieved 20 September 2026. https://priyalifescience.com/clinical-trials-europe/country/spain

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Listing here is informational and not medical advice; eligibility is determined by each study team. Looking for Irish sites? See the Ireland, UK or USA registers. For approved medicines, see the EMA Approvals Tracker.