Effect of GABAergic treatments on cortical plasticity and motor learning capacity in the subacute phase after stroke: a single-case experimental study (GABAPLAST)

Condition studied

Stroke

Investigational medicinal product(s)

Eligibility

Primary endpoint

Variation (Δ) in the amplitude of the motor evoked potential (MEP) induced by a Paired Associative Stimulation (PAS) protocol, expressed as the percentage change between pre-PAS and post-PAS measurements, assessed at each session

Endpoint detail

Cortical excitability (TMS): resting motor threshold, MEP amplitude and latency, assessed at each session., Motor learning performance: learning effect, rebound, and retention on SRTT and Target Jump tasks, assessed at each session., Safety: spontaneous report on adverse events, assessed at each session, Severity of the symptom that led to treatment prescription reported by the patient using the Patient Global Impression of Severity (PGI-S)