Perioperative Intravenous Metamizole in Laparoscopic Cholecystectomy: A rondomized, double blind, clinical trial.

Condition studied

Post operative pain relief in Patients undergoing laparoscopic cystectomy in day-surgery clinic

Investigational medicinal product(s)

Eligibility

Primary endpoint

The primary endpoint is the opioid consumption in IV morphine milligram equivalents (MME) administered peroperatively and during the first 3 postoperative hours.

Endpoint detail

Mean NRS (evaluated every 15 minutes until 60’ postoperative (+0’ +15’, +30’, +45’, +60’)), Number of given doses of rescue analgesia on PACU, Mean NRS hourly after PACU stay until discharge, Time to first rescue analgesia in PACU, Time to be ready for discharge from hospital Day Care Unit, Opioid consumption until discharge (IV morphine equivalents), Analgesic consumption (0-48h postoperative), Aldrete score (evaluated every 15, during PACU stay), PADSS (every hour from admission to Day Care Unit until discharge from hospital), QoR-15 POD1 and POD2