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Clinical Trials in the EU / 2025-524858-34-00
Completed Phase III

J3L-MC-EZEJ: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial of Lepodisiran to Investigate the Effect on Coronary Plaque in Adults With Elevated Lp(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event

2025-524858-34-00 · tracked via the Priya Life Science EU tracker
Sponsor
Eli Lilly & Co.
Sponsor type
Pharmaceutical company
Therapeutic area
Cardiovascular Diseases
Decision date
30/07/2026
Enrollment target
145
Sites
Hungary, Czechia, Spain, Netherlands

Condition studied

Lipoprotein(a), Atherosclerosis, Cardiovascular Diseases

Investigational medicinal product(s)

LepodisiranPlacebo to match LY

Eligibility

Age group
18-64 years
Sex
Female, Male

Primary endpoint

Percent Change from Baseline in Noncalcified Plaque (NCP) Volume

Official registry record

This page summarises publicly available CTIS data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View 2025-524858-34-00 on CTIS ↗ ← All trials in the EU