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Clinical Trials in the EU / 2025-524843-11-00
Ongoing Phase II

A Master Protocol of an Open-Label, Multi-Drug, Multi-Centre, Phase II Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumour Activity of Novel Combinations in Participants with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (LIBRA)

2025-524843-11-00 · tracked via the Priya Life Science EU tracker
Sponsor
AstraZeneca AB
Sponsor type
Pharmaceutical company
Therapeutic area
Neoplasms
Decision date
06/05/2026
Enrollment target
75
Sites
France, Italy, Spain

Condition studied

Non-Small Cell Lung Cancer

Investigational medicinal product(s)

RAMUCIRUMABRilvegostomigINFLIXIMABMYCOPHENOLATE MOFETILDatopotamab deruxtecan

Eligibility

Age group
18-64 years, 65+ years
Sex
Female, Male

Primary endpoint

Number of participants with adverse events (AE) and serious adverse events (SAE), Objective response rate (ORR)

Endpoint detail

Best Overall Response(BOR), Change in Target Lesion Tumor Size, Progression free survival (PFS), Disease Control Rate(DCR) at 12 Weeks, Duration Of Response (DoR), Overall Survival(OS), Serum concentration, Maximum plasma drug concentration (Cmax), Immunogenicity of study interventions in participants receiving treatment

Official registry record

This page summarises publicly available CTIS data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View 2025-524843-11-00 on CTIS ↗ ← All trials in the EU