Impact of epilepsy on the brainstem adenosine pathway and its relation with arousal and respiratory reactivity BRAVE

Condition studied

Neurology

Investigational medicinal product(s)

Eligibility

Primary endpoint

Comparison of the [18F]-CPFPX BPND in the brainstem structures involved in respiratory regulation under hypercapnic condition in patients with drug-resistant epilepsy with the one of healthy subjects

Endpoint detail

Comparison of the [18F]-CPFPX BPND in the cortical structures involved in respiratory regulation under hypercapnic condition in patients with drug-resistant epilepsy with the one of healthy subjects, Evaluating the relation between [18F]-CPFPX BPND in the brainstem structures involved in respiratory regulation under hypercapnic condition and the HCVR slope in patients with drug-resistant epilepsy and in healthy subjects, Comparison of the HCVR slope in patients with drug-resistant epilepsy and in heathly subjects, Evaluating the relation between the HCVR slope and the pattern of BOLD activiation during BH in patients with drug-resistant epilepsy and in heathly subjects, Comparing brainstem regional volumes on MRI of patients with drug-resistant epilepsy with the one of healthy subjects, Evaluating the relation between the brainstem regional volumes on MRI and the HCVR slope in patients with drug-resistant epilepsy and in heathly subjects, Evaluating the relation between mean daily intake of caffeine (mg/day) and the [18F]-CPFPX BPND in the brainstem and cortical structures