A PET-MRI study of serotoninergic brainstem pathway in patients with Dravet Syndrome - DRAPETONINE

Condition studied

neurology

Investigational medicinal product(s)

Eligibility

Primary endpoint

Comparison of the brainstem BPND of [18F]-MPPF across patients groups (DS and focal epilepsy)

Endpoint detail

Comparison of the brainstem BPND of [18F]-MPPF of each patients group (DS and focal epilepsy) with the one of healthy subjects, Comparison of the cortical BPND of [18F]-MPPF across patients groups (DS and focal epilepsy) and with the one of healthy subjects, aluating the relation between [18F]-MPPF PET brainstem regional distribution of 5HT1A receptors and inter-ictal respiratory function in patients with DS, Comparing brainstem regional volumes on MRI of patients with DS with the one of patients with drug-resistant focal epilepsy, Comparing brainstem regional volumes on MRI of each patients group (DS and focal epilepsy) with the one of healthy subjects, Evaluating the relation between the brainstem regional volumes on MRI and inter-ictal respiratory function in patients with DS