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Clinical Trials in the EU / 2025-522996-27-00
Ongoing Phase III

A randomized, open-label, multicenter, Phase 3 trial of ivonescimab alone or ivonescimab with ligufalimab versus pembrolizumab for the first-line treatment of recurrent and/or metastatic head and neck squamous cell carcinoma(HNSCC)

2025-522996-27-00 · tracked via the Priya Life Science EU tracker
Sponsor
Groupe Oncologie Radiotherapie Tete Cou
Sponsor type
Patient organisation/association
Therapeutic area
Neoplasms
Decision date
18/12/2025
Enrollment target
310
Sites
France, Spain, Belgium

Condition studied

recurrent and/or metastatic squamous cell carcinoma of the head and neck

Investigational medicinal product(s)

LigufalimabKEYTRUDA 25 mg/mL concentrate for solution for infusion.ivonescimabLigufalimab

Eligibility

Age group
18-64 years, 65+ years
Sex
Female, Male

Primary endpoint

Overall Survival

Endpoint detail

Objective response rate, Progression free survival, Disease control rate, safety assessments, pharmacokinetic characteristics, Immunogenicity assessment

Official registry record

This page summarises publicly available CTIS data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View 2025-522996-27-00 on CTIS ↗ ← All trials in the EU