TRITON-PN: A Phase 3, Global, Randomized, Open-Label Study to Evaluate the Efficacy and Safety of Nucresiran in Patients with Hereditary Transthyretin-Mediated Amyloidosis with Polyneuropathy (hATTR-PN)

Condition studied

Hereditary transthyretin-mediated amyloidosis with polyneuropathy

Investigational medicinal product(s)

Eligibility

Primary endpoint

Change from baseline in the Modified Neuropathy Impairment Score +7 (mNIS+7) compared to the external placebo group from the APOLLO study at Month 9

Endpoint detail

1. Change from baseline in Norfolk Quality of Life Diabetic Neuropathy (Norfolk QoL-DN) total score compared to the external placebo group from the APOLLO study at Month 9, 2. Percent reduction in serum TTR levels in the nucresiran group compared to the in-study vutrisiran group through Month 9, 3. Change from baseline in modified body mass index (mBMI) compared to the external placebo group from the APOLLO study at Month 9, 4. Change from baseline in the following parameters compared to the external placebo group from the APOLLO study at Month 18: o mNIS+7; o Norfolk QoL-DN total score; o mBMI; o Rasch-built Overall Disability Scale R-ODS; o Timed 10-meter walk test (10-MWT), 5. Percent reduction in serum TTR levels in the nucresiran group compared to the in-study vutrisiran group through Month 18, 6. Percent reduction in serum TTR levels in the nucresiran group compared to the in-study vutrisiran group at Week 6