The effect of colchicine, on insulin sensitivity in individuals with type 1 diabetes and systemic low-grade inflammation (INS1GHT)

Condition studied

Type 1 diabetes

Investigational medicinal product(s)

Eligibility

Primary endpoint

Change in M-value after four weeks of placebo/colchicine

Endpoint detail

Mean difference in M-value (adjusted to body surface area (BSA), Mean difference in M-value (adjusted to fat free mass), Mean difference in Insulin Sensitivity Index (ISI), Mean difference in average daily insulin dosage, Fold difference in Insulin sensitivity by estimated glucose disposal rate (eGDR), Fold difference in in fasting serum/plasma concentrations of inflammation markers hsCRP, IL-6, Tumour necrosis factor α