Cangrelor in endovascular stroke treatment with emergent carotid artery stenting (CANCAS)

Condition studied

ischemic stroke with intracranial large artery occlusion of the anterior cerebral circulation

Investigational medicinal product(s)

Eligibility

Primary endpoint

Carotid artery stent patency at 24 (+/-6) hours after stenting

Endpoint detail

Successful cerebral reperfusion according to modified Thrombolysis In Cerebral Infarction (mTICI) scores 2b-3, Clinical stroke severity according to the National Institutes Health Stroke Scale score at 24 (±6) hours and discharge from hospital or day 7, Modified Rankin Scale score at 90 (±14) days after stroke (telephone assessment allowed), Symptomatic intracranial haemorrhage (ECASS III definition), Major bleeding according to ISTH definition, Intracranial haemorrhage PH1, PH2, class 3 according to Heidelberg Bleeding Classification, In-hospital mortality