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Clinical Trials in the EU / 2025-520923-25-00
Completed Phase III

Trial of Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis (SMART-JIA)

2025-520923-25-00 · tracked via the Priya Life Science EU tracker
Sponsor
Duke Clinical Research Institute
Sponsor type
Laboratory/Research/Testing facility
Therapeutic area
Immune System Diseases
Decision date
10/02/2026
Enrollment target
45
Sites
Italy, Netherlands, Germany

Condition studied

Juvenile Idiopathic Arthritis

Investigational medicinal product(s)

Humira 40 mg solution for injection in pre-filled syringeXELJANZ 1 mg/mL oral solutionORENCIA 87.5 mg solution for injection in pre-filled syringeORENCIA 125 mg solution for injection in pre-filled syringeTyenne 162mg/0.9ml solution for injection in pre-filled syringeORENCIA 50 mg solution for injection in pre-filled syringeEnbrel 50 mg solution for injection in pre-filled syringeXELJANZ 5 mg film-coated tabletsHumira 20 mg solution for injection in pre-filled syringeEnbrel 25 mg solution for injection in pre-filled syringe

Eligibility

Age group
0-17 years
Sex
Female, Male

Primary endpoint

Minimal disease activity (MiDA) at Month 6 as assessed by the cJADAS10 less than or equal to 5

Endpoint detail

PROMIS® pain interference at Month 6, PROMIS® fatigue at Month 6, PROMIS® mobility at Month 6, Change in arthritis disease activity (cJADAS10 and JIA American College of Rheumatology Pediatric 70 [ACR 70]) at Month 6, Change in arthritis disease activity (cJADAS10) at Month 12

Official registry record

This page summarises publicly available CTIS data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View 2025-520923-25-00 on CTIS ↗ ← All trials in the EU