A single centre parallel-group randomized control trial of Magnetic Resonance Assessment of Variations in Effects of anaesthesia on renaL perfusion in children

Condition studied

Post-operative Acute Kidney Injury

Investigational medicinal product(s)

Eligibility

Primary endpoint

Differences in RBF, as measured by phase contrast imaging with mpMRI, between propofol and sevoflurane anesthesia.

Endpoint detail

The difference plasma renin concentration, measured by a blood sample, between propofol and sevoflurane anaesthesia, The difference in relation of RBF to systemic non-invasive blood pressure, between propofol and sevoflurane anaesthesia, Differences in regional and global renal oxygenation, as measured by Blood Oxygen Level Dependent (BOLD) signal via mpMRI, between propofol and sevoflurane anaesthesia., Differences in regional renal tissue perfusion, as measured by arterial spin labelling (ASL) with mpMRI, between propofol and sevoflurane anaesthesia