Hysteroscopic resection versus medical management of early pregnancy loss (HyME): a randomized controlled trial

Condition studied

Early pregnancy loss (< 10 weeks of gestation)

Investigational medicinal product(s)

Eligibility

Primary endpoint

Complete trophoblastic tissue expulsion, measured by the presence of a retained product of conception (RPOC) at ultrasound and diagnostic hysteroscopy ~1-2 month following intervention and the need for a secondary hysteroscopic resection

Endpoint detail

Intra-uterine adhesion rates at diagnostic hysteroscopy 1-2 months following complete evacuation, Pregnancy rates in the year following randomization, Rate of successful genetic analysis on the product of conception, Time needed to conceive, Complications occurring until 30 days post treatment, Patient well-being and quality of life evaluated by questionnaires 1-month and 3-months after the procedure