Brachial Plexus Nerve Block Versus Haematoma Block for Closed Reduction of Distal Radius Fracture in Adults - The BLOCK Trial. A Multicentre Randomised Controlled Trial.

NCT06678438 · tracked via the Priya Life Science Denmark tracker

Sponsor

Nordsjaellands Hospital

Phase

Phase 4

Started

2024-12-10

Last updated

2026-09-21

Condition(s) studied

Distal Radius FracturesFracture DislocationFracture Dislocation of Upper Limb JointColles' FractureClosed Reduction of Fracture and Application of Plaster Cast

Investigational drug(s) / intervention(s)

Ultrasound-guided brachial plexus blockHaematoma Block

Ultrasound-guided brachial plexus block: The block will be performed as either a lateral infraclavicular brachial plexus block or an axillary brachial plexus block

Haematoma Block: Participants will receive no peripheral nerve block and receive a haematoma block, with or without supplemental sedation and/or systemic analgesia for the closed reduction according to local guidelines and clinical practices

Study summary

The aim of the project is to evaluate the beneficial and harmful effects of an ultrasound-guided brachial plexus nerve block for patients with a distal radius (wrist) fracture in the need of realignment of fractured bone endings without cutting the skin (closed reduction), in comparison to a haematoma block, which is standard care in Denmark.

Every participant will receive one of the following types of anaesthesia for the realignment of the wrist fracture:

1. A nerve block of the arm (plexus brachialis block)
2. A haematoma block, which is the current standard anaesthesia in the emergency departments.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Adults (age ≥ 18 years) with a distal radius fracture in need of closed reduction Exclusion Criteria: * Patients who would never qualify for surgery according to local guidelines * Lack of informed consent * No Danish Central Person Register (CPR) number * Allergies to the trial medication * Distal radius fracture initially deemed to require surgery regardless of the outcome of the closed reduction * Open fractures (fracture-related wound requiring sutures) * Other fractures on the same extremity ((NOT including distal ulna fracture(s)) * Bilateral distal radius fractures both requiring closed reduction * Concomitant medical or surgical condition taking priority over the closed reduction of the distal radius fracture.

Primary outcome measure(s)

Cumulative proportion of patients with distal radius fracture surgery — 90 days after closed reduction

Trial sites (1)

Facility	City	Region	Status
Copenhagen University Hospital - North Zealand Hillerød	Hillerød	Capital Region

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06678438 on ClinicalTrials.gov ↗ ← All trials in Denmark