HD-tACS: The stimulation parameters are 40Hz and 2mA. The stimulation protocol is 20 minutes per session, 3 times per day, for a total of 10 consecutive days.
Sham HD-tACS: The stimulation parameters are 40Hz and 2mA. The stimulation protocol is 20 minutes per session, 3 times per day, for a total of 10 consecutive days. At the commencement and conclusion of each therapeutic session, a 30-second ramp-up stimulation and a 30-second ramp-down stimulation (totaling 60 seconds) are administered, respectively, while the current output of the device is maintained at zero throughout the intervening interval.
Study summary
This study aims to systematically explore the effectiveness of accelerated HD-tACS in treating AUD, particularly its efficacy in reducing alcohol craving and preventing relapse in AUD patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
55 Years
Healthy volunteers
No
Inclusion Criteria:
* Age range: 18-55 years old, gender not restricted;
* Meets the DSM-5 diagnostic criteria for alcohol use disorder (moderate to severe);
* AUDIT score ≥ 16;
* Baseline score after alcohol cue-induced stimulation is ≥ 3;
* Completed detoxification treatment before enrollment (moderate to severe), with detoxification duration of ≥ 7 days and ≤ 90 days;
* Has a primary school education or above, and can understand and complete the research assessment;
* Voluntarily participated in the study and signed the informed consent form.
Exclusion Criteria:
* Currently, there are other substance use disorders (except nicotine);
* Currently, there are schizophrenia, bipolar disorder or other severe psychotic disorders;
* Has a history of epilepsy or family history of epilepsy;
* Has a history of brain trauma, brain surgery or intracranial metal implants;
* Has received electroconvulsive therapy (ECT), transcranial electrical/magnetic/ultrasound stimulation within the past 6 months;
* Pregnant or lactating women;
* Other situations that the researchers consider unsuitable for participation in this study.
Primary outcome measure(s)
Change of Craving — baseline; The 2nd, 4th, 6th, 8th and 10th days during the intervention period; 4 weeks after treatment; 12 weeks after treatment Visual Analog Scale, range 0-100 point, the higher the score, the more one wants drugs.
Trial sites (1)
Facility
City
Region
Status
Shanghai Mental Health Center
Shanghai
Shanghai Municipality
More Shanghai Mental Health Center trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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