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Clinical Trials in China / NCT07799636
Recruiting Observational

Early Warning and Stratified Diagnosis of Postoperative Respiratory Failure Based on Ventilator Waveform Image Features

NCT07799636 · tracked via the Priya Life Science China tracker
Sponsor
West China Hospital
Phase
Observational
Started
2025-12-29
Last updated
2026-09-02

Condition(s) studied

Postoperative Respiratory Failure

Study summary

I. Study Background Postoperative respiratory failure (PRF) is a common and serious complication following major surgery, significantly increasing the rates of ICU admission and mortality. Traditional early warning methods primarily rely on blood gas analysis and vital sign monitoring, which are often delayed and may fail to identify early pathological changes in a timely manner. In recent years, ventilator waveforms, as dynamic information that directly reflects respiratory mechanics and airway conditions, have gradually attracted increasing attention in the optimization of respiratory support. International studies have suggested that analysis of ventilator waveform features may help identify patient-ventilator asynchrony, excessive spontaneous respiratory effort, ventilation-perfusion mismatch, and ventilator-related complications. In China, although a limited number of studies have explored this area, most have focused on individual parameters and lack systematic and prospective clinical validation. Therefore, this study aims to establish a large prospective cohort and integrate image feature extraction with stratified diagnostic modeling to achieve early warning and risk stratification of postoperative respiratory failure. This study is expected not only to address the current gap in this field in China but also to provide evidence-based support for precision respiratory management and improved clinical outcomes.

Eligibility

Sex
ALL
Min age
Max age
Healthy volunteers
Accepted
Inclusion Criteria: * Age ≥18 years; * Patients receiving mechanical ventilation after surgery and transferred directly to the ICU; * Patients expected to require or actually requiring mechanical ventilation for more than 24 hours after surgery; * Patients or their legally authorized representatives providing written informed consent. Exclusion Criteria: * Respiratory failure occurring before surgery; * Severe pulmonary disease diagnosed before surgery, including but not limited to severe chronic obstructive pulmonary disease (COPD; GOLD stage 3-4), severe interstitial lung disease (PaO₂/FiO₂ \<300 mmHg), active pneumonia, and severe pulmonary hypertension; * Preoperative mechanical ventilation for \>48 hours; * A decision made immediately after surgery to withhold or withdraw active treatment, including invasive mechanical ventilation; * Expected survival of less than 48 hours; * Inability to connect to or record the required ventilator waveform data and/or electronic medical record data; * Other severe underlying diseases, including but not limited to end-stage liver disease, dialysis-dependent renal failure, and advanced malignancy with a short expected survival.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Chi Zhang Chengdu Sichuan Recruiting

More West China Hospital trials in China

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07799636 on ClinicalTrials.gov ↗ ← All trials in China