Postoperative delirium is a common acute central nervous system syndrome, which often occurs 1-5 days after surgery. Postoperative delirium can prolong the length of hospital stay, increase the mortality rate, and is also associated with long-term postoperative cognitive dysfunction. However, the pathogenesis of postoperative delirium in elderly patients undergoing neurosurgical procedures, who are at high risk for ostoperative delirium, remains unclear. This study aims to elucidate the underlying mechanisms of postoperative delirium in this population and inform the development of effective prevention and treatment strategies.
Eligibility
Sex
ALL
Min age
60 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients undergoing elective craniotomy for intracranial tumour resection
* Patients who will provide written informed consent
Exclusion Criteria:
* Patients with severe preoperative cognitive impairment precluding subsequent assessments
* History of psychotropic medication use
* Previous history of neurosurgical operation
* Severe bradycardia (heart rate \< 40 beats per minute)
* Sick-sinus syndrome or atrioventricular block of grade Ⅱ or above
* Severe hepatic insufficiency (Child-Pugh grade C)
* Renal failure requiring renal replacement therapy
Primary outcome measure(s)
The association between intraoperative hypotension and postoperative delirium — The surgery day and twice a day (from 8:00 to 10:00 and from 18:00 to 20:00) during the first postoperative 5 days. Intraoperative hypotension was defined by absolute mean arterial pressure (MAP) thresholds (sustained MAP \< 75, 70, 65, or 60 mm Hg for \> 1 min) or relative MAP reductions (10%, 20%, 30%, or 40% below preoperative baseline). The Confusion Assessment Method for the Intensive Care Unit scale (CAM-ICU) or 3 min diagnostic interview for CAM (3D-CAM) will be applied to assess postoperative delirium.
Trial sites (1)
Facility
City
Region
Status
Beijing Tian Tan Hospital, Capital Medical University
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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