CT Imaging and Clinical Features to Predict Outcomes in Patients With Gastric Cancer

Condition(s) studied

Investigational drug(s) / intervention(s)

No intervention (observational study): No intervention or treatment will be assigned by the study protocol. All diagnostic and treatment decisions, including surgery, chemotherapy, immunotherapy, or combined treatment, will be made by treating clinicians as part of routine clinical care. The predefined CT radiomics-based prognostic model will be applied to collected imaging and clinical data for research validation only. Model-generated predictions will not be used to guide or modify clinical treatment decisions.

Study summary

The goal of this prospective observational study is to evaluate how well a previously developed prediction model can estimate outcomes in adults with gastric cancer. The model combines information from computed tomography (CT) images obtained before treatment with routine clinical information. The main questions are how well the model predicts how long participants live after treatment begins and whether their cancer progresses.

Participants will receive their usual medical care. Researchers will collect pretreatment CT images, basic clinical and tumor information, laboratory and tumor marker results, treatment information, and follow-up outcomes obtained during routine care. These data will be entered into the predefined prediction model, and the model's predictions will be compared with what actually happens during follow-up.

The study will not change the participants' usual treatment. Model predictions will be used for research purposes only and will not be used to make treatment decisions.

Eligibility

Primary outcome measure(s)

• Overall Survival (OS) — From initiation of treatment until death or last follow-up, assessed up to 12 months
  Overall survival is defined as the time from initiation of initial treatment to death from any cause. Participants who are alive at the last available clinical follow-up will be censored at the date of last follow-up. Survival status will be obtained from medical records, telephone follow-up, and death certificates.

Trial sites (1)

More Union Hospital, Tongji Medical College, Huazhong University of Science and Technology trials in China

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