Closed-loop TBS Targeting rPO for the Core Clinical Features of the Methamphetamine Use Disorder

NCT07775807 · tracked via the Priya Life Science China tracker

Sponsor

Shanghai Mental Health Center

Phase

Not applicable

Started

2026-08

Last updated

2026-08-20

Condition(s) studied

Methamphetamine Use DisorderSubstance Use DisorderCue-reactivityCraving

Investigational drug(s) / intervention(s)

Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO

Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO: Participants receive theta-burst stimulation (TBS) over the right parietal-occipital cortex (rPO), triggered by real time by EEG signals recorded during a cue-reactivity task. This closed-loop protocol aims to deliver stimulation precisely during neural states associated with cue-induced reactivity.

Study summary

The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use disorder (MUD), such as cue-reactivity and impaired inhibitory control.

The main questions it aims to answer are:

Can closed-loop rPO-TBS significantly reduce cue-reactivity, as measured by a Visual Analog Scale (VAS) and a cue-reactivity task? Does closed-loop stimulation enhance cognitive control, assessed by performance on the Stop Signal Task (SST)?

Researchers will administer closed loop TBS to determine whether it can improve the core symptoms of MUD.

Participants will:

Complete a single closed-loop sessions. Receive theta-burst stimulation targeting the right parietal-occipital cortex while complete the cue-reactivity task.

Undergo cue-reactivity assessment using a Visual Analog Scale (VAS) and complete the Stop Signal Task (SST) before and after the stimulation session.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Aged 18 years old or older, ....with at least 9 years of education (junior high school or above) or able to fully understand the task. * Meets DSM-5 for mild/severe amphetamine-type substance use disorder. * History of amphetamine-type substance use for no less than 1 year, with use at least once per week. * Has not received pharmacological treatment for substance use. Exclusion Criteria: * Presence of any organic disease, or diagnosis of any other psychiatric disorder according to DSM-5 (e.g., bipolar disorder, major depression disorder). * Contraindications to TMS, as assessed by the Transcranial Magnetic Stimulation Adult Safety Screen (TASS). * Inability to complete assessments, treatment procedures, or follow-up due to cognitive or behavioral limitations.

Primary outcome measure(s)

Cue-Induced Neural Reactivity During Before and After Stimulation — During cue-reactivity task in training and stimulation phases of each session.
EEG signals will be recorded while participants perform a cue-reactivity task during both the training phase (no stimulation) and the stimulation phase (with TBS). The primary outcome will be changes in cue-induced neural reactivity, defined by EEG features such as event-related potentials (ERPs) and power spectral density (e.g., theta or alpha power) in response to methamphetamine-related cues.

Trial sites (1)

Facility	City	Region	Status
Shanghai Mental Health Center, 200030	Shanghai	Shanghai Municipality

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Other trials for the same condition

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07775807 on ClinicalTrials.gov ↗ ← All trials in China