Effects of Exercise Snacks on Physical Health and Cognitive Function in Individuals With Intellectual Disabilities

NCT07759232 · tracked via the Priya Life Science China tracker

Sponsor

University of Macau

Phase

Not applicable

Started

2026-11-16

Last updated

2026-08-12

Condition(s) studied

Intellectual Disability

Investigational drug(s) / intervention(s)

High-Intensity Interval TrainingExercise Snacks

High-Intensity Interval Training: Acute high-intensity interval training protocol: 10 × 6 s high-knee exercise with 9 s rest between sets, completed in a single afternoon session.

Exercise Snacks: Twice-daily short-bout exercise snacks. Each session includes 5 sets of 6-second high-knee exercise with 9 seconds rest between sets.

Study summary

Intellectual disability (ID) is a neurodevelopmental disorder accompanied by sedentary lifestyles, which worsens cognitive function and physical health. Short-duration high-frequency exercise snacks (ES) may be a feasible intervention for adults with ID. This randomized controlled crossover study aims to explore the acute effects of exercise snacks, conventional HIIT and daily routine control on cognitive function, stereotyped behaviors and prefrontal cortex activation in adults with mild to moderate ID. All participants will receive three intervention conditions with a 1-week washout period between each trial. Neurophysiological indicators including EEG and heart rate variability will be measured to reveal the underlying mechanisms.

Eligibility

Sex

ALL

Min age

18 Years

Max age

35 Years

Healthy volunteers

Inclusion Criteria: 1. Aged 18-35 years old; 2. Clinically diagnosed mild to moderate intellectual disability; 3. Able to follow simple verbal instructions and complete exercise protocols; 4. No contraindications for moderate physical activity confirmed by medical inquiry; 5. Participants or legal guardians provide written informed consent; 6. Maintain stable daily routine and do not participate in other structured exercise programs during the trial. Exclusion Criteria: 1. Severe physical disabilities, orthopedic injury or neurological disorders that restrict movement; 2. History of cardiovascular disease, uncontrolled hypertension or other exercise contraindications; 3. Current psychiatric medication that significantly affects motor or cognitive function; 4. Inability to cooperate with EEG and physiological signal collection; 5. Pregnancy; 6. Participation in other interventional studies within the past 3 months.

Primary outcome measure(s)

Changes in cognitive function assessed by cognitive test battery — Baseline and immediately after the acute intervention
Changes in cognitive performance measured after each intervention condition, including attention and executive function.

Trial sites (1)

Facility	City	Region	Status
Hangzhou First Social Welfare Institute	Hangzhou	Zhejiang

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07759232 on ClinicalTrials.gov ↗ ← All trials in China