PyroEVs/PLIN3 Mediate Lipid Droplet-Mitochondrial Coupling in Sepsis Endothelial Injury

Condition(s) studied

Investigational drug(s) / intervention(s)

No Intervention: Observational Cohort: No intervention

Study summary

Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients.

Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers.

Inclusion Criteria:

1. Presence of confirmed or suspected infection;
2. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline;
3. Signed informed consent. Exclusion Criteria: Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.

Primary outcome: 28-day mortality, SOFA score

Eligibility

Primary outcome measure(s)

• Concentration of pyroptic extracellular vesicles (PyroEVs) in plasma — Day 1
  The concentration of pyroptic extracellular vesicles (PyroEVs) in plasma will be measured using nanoparticle tracking analysis. Results will be reported as particles per milliliter (particles/mL).
• Concentration of PLIN3 in plasma — Day 1
• 28-day mortality — 28 days
• SOFA score — 28 days

Trial sites (1)

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