A Prospective Clinical Study Observed the Effects of Tubeless Anesthesia Method That Preserves Spontaneous Breathing and the Double-lumen Bronchial Intubation on the Brain Health During the Perioperative Period
This project conducts a prospective cohort study. By using multiple questionnaire survey methods such as the Pittsburgh Sleep Quality Index (PSQI) electronic wristband, QOR15, Pain Catastrophizing Scale (PCS), European Five-Dimensional Health Scale (EQ-5D), Revised American Pain Society Patient Follow-up Questionnaire (APS-POQ-R), Mini-Mental State Examination (MMSE), as well as perioperative stress and related indicators, hypothalamic-pituitary-adrenal axis (HPA) endocrine indicators, sublingual microcirculation, electroencephalogram, etc., comprehensive assessment is made of the correlations between the two different anesthesia methods of Tubeless retention of spontaneous breathing and double-lumen bronchial intubation and postoperative sleep, chronic pain and cognitive function, to construct a perioperative brain health safety system to improve prognosis; at the same time, optimize the perioperative sedation and analgesia plan and promote the postoperative brain health recovery of patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria:
* Patient age: 18 - 75 years old
* Patients meeting the standards of the American Society of Anesthesiologists (ASA) I-III grade and the New York Heart Association (NYHA) I-II class
* Body Mass Index (BMI) \< 30 kg/m2
* Intraoperative blood loss less than 300 ml
* No severe cardiac or pulmonary dysfunction \[first-second forced vital capacity (FEV1%) predicted value\] \> 50%, ejection fraction (EF) \> 50%
* No contraindications related to paravertebral nerve block and intercostal nerve block
* Able to sign the informed consent form and possess communication, reading and writing abilities
* Postoperative hospital stay of at least one day
* No preoperative sleep disorders, no cognitive dysfunction (PSQI ≤ 10 points, PCS ≤ 38 points, MMSE \> 27 points)
Exclusion Criteria:
* Already diagnosed with a mental disorder or had a preoperative Mini-Mental State Examination (MMSE) score of less than 27
* History of opioid abuse
* Patients who were admitted to the ICU after surgery
* Have severe cardiovascular, respiratory diseases
* Experienced critical rescue during or after the surgery
* Complicated with coagulation dysfunction, severe hypoxia or hypercapnia, or liver and kidney dysfunction
* Difficult airway management
* Changed anesthetic agent or surgical plan
* Severe lacunar cerebral infarction, ischemic stroke or other neurological diseases
* Changed anesthetic agent or surgical plan during the surgery;
Primary outcome measure(s)
Concentration of cognitive function biomarkers in the serum samples of 400 patients — Before the start of the surgery (T1), at the end of the surgery (T2), and on the first day after the surgery (T3) At time points T1, T2, and T3, 5 ml of peripheral venous blood was collected to test the biological indicators of postoperative cognitive function.
Concentrations of HPA axis-related indicators in the serum samples of 400 patients — Before the start of the surgery (T1), at the end of the surgery (T2) At the TI-T2 time point, 5 ml of peripheral venous blood was collected for the detection of HPA axis-related indicators.
The concentrations of laboratory test indicators in the serum samples of 400 patients — Before the start of the surgery (T1), and on the first day after the surgery (T3) Record the laboratory test indicators at time points T1 and T3
Trial sites (1)
Facility
City
Region
Status
the First Affiliated Hospital of Guangzhou Medical University
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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