National Cohort Study on Infant Gut Microbiota and Nutrition

Condition(s) studied

Investigational drug(s) / intervention(s)

Fecal sample collection and gut microbiome profiling: This study is purely observational with no therapeutic or invasive clinical interventions implemented. We only collect non-invasive fecal specimens from enrolled healthy infants and children aged 0-6 years across China, perform microbial genome sequencing and microbial isolation culture to analyze gut microbiota characteristics, and construct a national pediatric gut microbiome atlas. No drugs, medical devices or clinical treatment adjustments are given to participants throughout the research.

Study summary

This study plans to collect 106,667 fecal samples from Chinese infants and children under 6 years old, with multi-dimensional stratification based on geographic location, mode of delivery, antibiotic exposure, and developmental stage. Fecal gut microbiota will be profiled to construct a gut microbiome atlas, establish quantitative analytical models linking geographic regions, physiological phenotypes and microbial signatures, and identify key microbial biomarkers associated with core healthy phenotypes.

Eligibility

Primary outcome measure(s)

• Establish a national gut microbiome atlas of infants and children aged 0-6 years covering all 34 provincial-level administrative regions in China, incorporating subjects across distinct age brackets and geographic backgrounds — Baseline (single time point at enrollment)

Trial sites (1)