A Phase IIa Study of JAB-8263 in Patients With Active Rheumatoid Arthritis

Inclusion Criteria: 1. Age ≥18 years old and \<75 years old at the time of signing the informed consent form, regardless of gender; 2. Active rheumatoid arthritis, ESR or C-reactive protein\> upper limit of normal 3. Meets the 2010 American College of Rheumatology ACR/EULAR RA classification standards 4. Participants have recovered from adverse reactions to previous antirheumatic treatment. Exclusion Criteria: 1. Use of topical glucocorticoids within 2 weeks before the first dose of investigational product or have received epidural, intraarticular, intramuscular, oral or intravenous glucocorticoids within 4 weeks, and do not use adrenocorticotropin; 2. Use of NSAIDs within 1 week before first dose of investigational product 3. Known or suspected allergies to the investigational product or any of its components; 4. Current active shingles virus infection, including shingles or herpes simplex types 1 and 2 (confirmed by physical examination and medical history); participants had a history of severe herpes infection, including any disseminated disease, shingles in multiple skin areas, herpes encephalitis, ocular herpes, or recurrent shingles (2 episodes greater than or equal to 2 episodes within 2 years); 5. Have evidence of active tuberculosis (TB) or have previously had evidence of active TB and have not received appropriate documented treatment;