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Clinical Trials in China / NCT07662044
Recruiting Phase 3

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus

NCT07662044 · tracked via the Priya Life Science China tracker
Sponsor
AstraZeneca
Phase
Phase 3
Started
2026-07-06
Last updated
2026-08-31

Condition(s) studied

Type 2 Diabetes Mellitus

Investigational drug(s) / intervention(s)

ElecoglipronDapagliflozinElecoglipron-matched placeboDapagliflozin-matched placebo

Elecoglipron: Elecoglipron is administered orally once daily.

Dapagliflozin: Dapagliflozin administered orally once daily.

Elecoglipron-matched placebo: A placebo matching elecoglipron, administered orally once daily.

Dapagliflozin-matched placebo: A placebo matching dapagliflozin, administered orally once daily.

Study summary

The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron alone or in combination with dapagliflozin compared with placebo in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated with other background glucose-lowering medication.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Diagnosed with Type 2 Diabetes Mellitus (T2DM) for at least 90 days prior to screening * T2DM inadequately managed with lifestyle management alone or on stable treatment with other background glucose-lowering medication * HbA1c value of ≥ 7% to ≤ 10.5% (53 to 91.3 mmol/mol) * Body mass index (BMI) of ≥ 23 kg/m2 at screening * Stable body weight (self-reported or documented) for 90 days prior to screening Exclusion Criteria: * Type 1 diabetes, secondary forms of diabetes (including congenital forms), or history of ketoacidosis or hyperosmolar coma * Currently receiving or anticipated to receive, therapeutic intervention for diabetic retinopathy and/or macular edema * Have had more than one episode of severe hypoglycemia within 180 days prior to screening or has a history of hypoglycemia unawareness or poor recognition of hypoglycemic symptoms * Clinically significant condition affecting the upper GI tract or chronic use of any medication that affects gastric motility or gastric emptying * History of acute or chronic pancreatitis * Severe congestive heart failure (New York Heart Association IV) * History/family history of medullary thyroid cancer or multiple endocrine neoplasia type 2

Primary outcome measure(s)

Trial sites (149)

FacilityCityRegionStatus
Research Site Birmingham Alabama Not Yet Recruiting
Research Site Daphne Alabama Not Yet Recruiting
Research Site Lomita California Not Yet Recruiting
Research Site Los Alamitos California Not Yet Recruiting
Research Site San Diego California Suspended
Research Site Walnut Creek California Suspended
Research Site Englewood Colorado Not Yet Recruiting
Research Site Bridgeport Connecticut Not Yet Recruiting
Research Site Jacksonville Florida Not Yet Recruiting
Research Site Orlando Florida Not Yet Recruiting
Research Site Conyers Georgia Not Yet Recruiting
Research Site Decatur Georgia Not Yet Recruiting
Research Site Hinesville Georgia Not Yet Recruiting
Research Site El Dorado Kansas Not Yet Recruiting
Research Site Newton Kansas Not Yet Recruiting
Research Site Lexington Kentucky Not Yet Recruiting
Research Site Covington Louisiana Not Yet Recruiting
Research Site Bowie Maryland Not Yet Recruiting
Research Site Southfield Michigan Not Yet Recruiting
Research Site Kansas City Missouri Not Yet Recruiting
Research Site St Louis Missouri Not Yet Recruiting
Research Site Las Vegas Nevada Not Yet Recruiting
Research Site Anderson South Carolina Not Yet Recruiting
Research Site Knoxville Tennessee Not Yet Recruiting
Research Site Fort Worth Texas Suspended
Research Site Irving Texas Not Yet Recruiting
Research Site Renton Washington Not Yet Recruiting
Research Site Buenos Aires Argentina Not Yet Recruiting
Research Site CABA Argentina Not Yet Recruiting
Research Site Caba Argentina Not Yet Recruiting
Research Site Ciudad de Buenos Aires Argentina Not Yet Recruiting
Research Site Mar del Plata Argentina Not Yet Recruiting
Research Site San Nicolás Argentina Not Yet Recruiting
Research Site San Vicente Argentina Not Yet Recruiting
Research Site Santa Fe Argentina Not Yet Recruiting
Research Site Baotou China Not Yet Recruiting
Research Site Binzhou China Not Yet Recruiting
Research Site Cangzhou China Not Yet Recruiting
Research Site Changsha China Not Yet Recruiting
Research Site Chengdu China Not Yet Recruiting

+ 109 more sites — see the full list on the official registry below.

On this site

📄 Farxiga (dapagliflozin) drug profile →

More AstraZeneca trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07662044 on ClinicalTrials.gov ↗ ← All trials in China