Risk Factor Assessment for Acute Pulmonary Hypertension Crisis

NCT07653958 · tracked via the Priya Life Science China tracker

Sponsor

Peking Union Medical College Hospital

Phase

Observational

Started

2026-06-17

Last updated

2026-06-22

Condition(s) studied

Pulmonary HypertensionPulmonary Hypertension Crisis

Study summary

The goal of this observational study is to learn about pulmonary hypertension crisis (PHC) - a severe, and often fatal complication - in patients with pulmonary hypertension (PH). The main questions this study aims to answer are:

What are the clinical and hemodynamic features of PHC, and what underlying pathophysiological mechanisms cause it to develop? Can these features be used to diagnostic PHC, predict who is at risk of developing it or dying from it, and develop targeted prevention and treatment of PHC?

A multi-center registry platform and biobank will be established to enroll and follow up patients with PH. Clinical data, hemodynamic measurements, and biological specimen will be collected. Risk prediction and early warning tools of PHC will be developed.

Eligibility

Sex

ALL

Min age

—

Max age

—

Healthy volunteers

Inclusion Criteria: * Pulmonary hypertension confirmed by mean pulmonary arterial pressure (mPAP) over 20 mmHg measured by right heart catheter * At least once per year of follow-up data collection record Exclusion Criteria: * Patients with missing baseline or follow-up data * Complicated by other diseases with significant influence on survival, such as acute coronary syndrome, malignancy, etc. * Complicated by other diseases with significant influence on hemodynamics, such as sepsis, acute left heart failure, and acute pulmonary embolism, etc. * Receiving medications with significant influence on hemodynamics

Primary outcome measure(s)

Pulmonary hypertension crisis — From enrollment to 3 years after enrollment
Critical increase of pulmonary vascular resistance accompanied by right heart dysfunction and systemic hypoperfusion
28 day mortality attributed to pulmonary hypertension crisis — From hospitalization to 28 days
Death attributed to pulmonary hypertension crisis within 28 days of hospitalization

Trial sites (4)

Facility	City	Region	Status
Guangdong Province People's Hospital	Guangzhou	Guangdong	Recruiting
Yan'an Affiliated Hospital of Kunming Medical University	Kunming	Yunnan	Recruiting
Peking Union Medical College Hospital	Beijing	China	Recruiting
Shanghai Pulmonary Hospital	Shanghai	China	Recruiting

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Other trials for the same condition

PH-DyPred: A Multimodal Dynamic Risk Prediction Study in Pulmonary Hypertension Recruiting

Real-World Study of PADN for the Treatment of PAH Recruiting

Safety Surveillance of Targeted Drugs for Pulmonary Hypertension Using a Computerized Follow-up System: a Nationwide Cohort Study Recruiting

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Clinical Characteristics and Outcomes of Patients With Pulmonary Hypertension Associated Right Heart Failure Active, not recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07653958 on ClinicalTrials.gov ↗ ← All trials in China