Changes in Regional Ventilation-Perfusion Match Following Percutaneous Transluminal Angioplasty for Arteriovenous Graft Thrombosis

NCT07613632 · tracked via the Priya Life Science China tracker

Sponsor

First Affiliated Hospital of Wannan Medical College

Phase

Observational

Started

2024-10-24

Last updated

2026-05-29

Condition(s) studied

Arteriovenous Graft ThrombosisEnd Stage Renal Disease on Dialysis

Investigational drug(s) / intervention(s)

Electrical Impedance Tomography (EIT) Monitoring

Electrical Impedance Tomography (EIT) Monitoring: Non-invasive 16-electrode EIT belt applied at the 4th intercostal level. Continuous data acquisition begins 10 min pre-PTA, continues throughout balloon angioplasty, and up to 30 min post-recanalization. No alteration to standard clinical care.

Study summary

Patients with end-stage renal disease (ESRD) often require arteriovenous grafts (AVG) for hemodialysis. AVG thrombosis is a common complication, usually managed by percutaneous transluminal angioplasty (PTA) to restore blood flow. PTA achieves patency by balloon-mediated compression and fragmentation of thrombus. Small thrombus fragments may enter the venous circulation and cause transient pulmonary microembolism, leading to ventilation-perfusion (V/Q) mismatch. This study uses electrical impedance tomography (EIT) to noninvasively monitor short-term changes in regional ventilation and perfusion during and after PTA, exploring the immediate pulmonary physiological consequences of thrombus fragmentation and revascularization in dialysis patients.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria 1. Age ≥ 18 years. 2. Diagnosis of end-stage renal disease receiving maintenance hemodialysis. 3. Documented AVG thrombosis requiring PTA. 4. Able to cooperate and tolerate EIT monitoring. 5. Provided written informed consent. Exclusion Criteria 1. Severe respiratory failure incompatible with supine position. 2. Thoracic skin condition or deformity preventing EIT electrode placement. 3. Acute pulmonary embolism or acute pulmonary edema before procedure. 4. NYHA Class IV heart failure or hemodynamic instability. 5. Pregnancy or breastfeeding. 6. Any other circumstance judged unsuitable by investigator.

Primary outcome measure(s)

Change in Ventilation-Perfusion Matching Index — Baseline (10 min before PTA), immediate post-recanalization, 10, 20, 30 minutes, and procedure end.
Quantitative index derived from EIT ventilation and perfusion maps, indicating spatial regional correlation of air and blood flow distribution.

Trial sites (1)

Facility	City	Region	Status
The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)	Wuhu	China	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07613632 on ClinicalTrials.gov ↗ ← All trials in China