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Clinical Trials in China / NCT07611266
Recruiting Observational

Prediction Model of Colorectal Adenoma Recurrence-Carcinogenesis Risk With TCM-WM Multimodal Feature Fusion

NCT07611266 · tracked via the Priya Life Science China tracker
Sponsor
Beijing Friendship Hospital
Phase
Observational
Started
2025-06-01
Last updated
2026-05-28

Condition(s) studied

Colorectal Cancer Control and Prevention

Study summary

This project focuses on developing a risk prediction model for the recurrence and malignant transformation of colorectal adenomas by integrating multimodal features from both Traditional Chinese Medicine (TCM) and Western medicine. Led by Dr. Wei Hongtao from Beijing Friendship Hospital, Capital Medical University, the primary objective is to mine clinical characteristics from both medical systems to construct a robust predictive model. The research encompasses several key aspects: a multicenter, large-sample cohort study design with a clearly defined sample size and calculation basis; patient recruitment from multiple institutions nationwide to form training and validation sets; and strict adherence to standardized TCM and Western diagnostic criteria. Through comprehensive observation of demographic, TCM clinical (e.g., syndromes, tongue and pulse diagnosis), and Western clinical features, the study ensures data accuracy via rigorous monitoring and follow-up. Various algorithms are employed to extract and analyze these multi-source features-including endoscopic data-to build and evaluate the prediction model. Furthermore, the study aims to identify dominant subgroups to optimize TCM intervention strategies. Key performance indicators include establishing the risk model, identifying target populations, publishing high-quality papers, and training graduate students. By innovatively constructing this multimodal fusion model, the project provides a novel perspective and evidence-based foundation for the prevention and treatment of colorectal adenomas using TCM.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: * Meet the diagnostic criteria for colorectal adenoma (Western medicine) and the relevant TCM syndromes. * Aged 18 years or older. * Willing to undergo regular follow-up examinations (including colonoscopy and laboratory tests) and sign the informed consent form. Exclusion Criteria: * Pregnant or lactating women. * History of Crohn's disease, ulcerative colitis, or other malignancies. * Previous history of radiotherapy, chemotherapy, or gastrointestinal surgery. * Hereditary polyposis syndromes (e.g., familial adenomatous polyposis, MUTYH-associated polyposis, or hamartomatous polyposis syndrome). * Severe cognitive impairment, dementia, or mental illness. * Severe cardiovascular or cerebrovascular diseases, or hematological system disorders.

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Beijing Friendship Hospital Affiliated to Capital Medical University Beijing Beijing Municipality Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07611266 on ClinicalTrials.gov ↗ ← All trials in China