Morphological-Gene-Clinical Phenotype Correlation Study of the Long Anterior Zonule

Condition(s) studied

Investigational drug(s) / intervention(s)

Control: Routine cataract patient, no signs of LAZ, intraocular pressure ≤21 mmHg, and no history of glaucoma, pigment dispersion syndrome, or other eye diseases that clearly affect the anterior segment structure.

Long anterior zonules: Patients with cataracts combined with LAZ were independently evaluated by at least two senior ophthalmologists under slit-lamp examination or a 3D visualization system, and were required to meet the predefined diagnostic criteria for LAZ.

LAZ Pedigree: First-degree and above relatives of the LAZ proband, aged ≥18 years, regardless of the presence or absence of LAZ or related ocular disease phenotypes.

Study summary

Long anterior zonules (LAZ) is an anatomical anomaly of the anterior segment in which zonular fibers extend abnormally forward onto the anterior lens capsule. It is potentially associated with glaucoma, late-onset retinal degeneration, and increased risks during cataract surgery. This study introduces a 3D visualization system to enhance the detection rate of LAZ. By integrating multiple imaging modalities, it systematically assesses the morphological characteristics of LAZ, aiming to provide an evidence-based foundation for subsequent efforts to establish diagnostic consensus, optimize preoperative assessments for glaucoma and cataract surgery. By elucidating the genetic mechanisms and genotype-phenotype correlations of LAZ, this research can provide theoretical support for the early identification of high-risk populations, genetic consultation, and personalized treatment.

Eligibility

Primary outcome measure(s)

• Axial length — 1 day pre-op
  Axial length, anterior chamber depth, lens thickness, corneal curvature, corneal diameter
• Anterior chamber depth — 1 day pre-op
• Lens thickness — 1 day pre-op
• Corneal curvature — 1 day pre-op
• Corneal diameter (WTW) — 1 day pre-op
• Imaging of LAZ morphology and distribution — 1 day pre-op
  The images and videos about slit lamp and 3D visualization system.
• Gene sequencing — through study completion, an average of 1 year
  Identification of pathogenic genes

Trial sites (1)