Nudging for Anticoagulation Adherence in Atrial Fibrillation

NCT07543393 · tracked via the Priya Life Science China tracker

Sponsor

Sun Yat-sen University

Phase

Not applicable

Started

2026-06-30

Last updated

2026-06-26

Condition(s) studied

Atrial Fibrillation (AF)

Investigational drug(s) / intervention(s)

Nudge Intervention

Nudge Intervention: Participants receive a multi-component nudge intervention including: an educational video on atrial fibrillation and stroke prevention; a personalized action plan linking pill-taking to a daily routine; a paper medication calendar with check-off grid and visual cues; tapered SMS reminders (weekly frequency declines from 3 to 1 over 8 weeks); weekly feedback messages; and a mid-point telephone call at week 4.

Study summary

The goal of this clinical trial is to learn if a nudging intervention (using text message reminders, a medication calendar, and action planning) can help people with atrial fibrillation take their blood-thinning medication (anticoagulants) as prescribed.

The main questions it aims to answer are:

Does the nudging intervention improve medication adherence compared to usual care?

How does the intervention affect patients' beliefs about their medication and the automaticity of pill-taking?

Is the intervention cost-effective?

Researchers will compare participants who receive the nudging intervention with those who receive usual care.

Participants will:

Watch a short educational video about atrial fibrillation and stroke prevention

Make a personal plan to take their medication at the same time each day (for example, after breakfast)

Receive text message reminders 1 to 3 times per week, with fewer messages over time

Get a medication calendar to track daily doses

Answer a few questionnaires at the start, at 8 weeks, and at 12 weeks

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥18 years Diagnosed with non-valvular atrial fibrillation (AF) confirmed by medical records Prescribed oral anticoagulants (e.g., warfarin, rivaroxaban, apixaban, dabigatran, edoxaban) for at least 3 months Own a personal mobile phone capable of receiving SMS messages Willing and able to provide written informed consent Exclusion Criteria: * Severe cognitive impairment or psychiatric disorder that would preclude completion of questionnaires or adherence to the intervention Life expectancy \<6 months due to comorbid conditions Currently enrolled in another medication adherence intervention study Unable to read or understand Chinese (since validated Chinese scales are used)

Primary outcome measure(s)

Medication Adherence measured by the Medication Adherence Estimation and Differentiation Scale (MEDS) — Baseline (week 0), end of intervention (week 8), and follow-up (week 12)
The MEDS is a 16-item, 5-point Likert scale (1=never to 5=always) assessing medication adherence across five dimensions: side effects, drug addiction, drug cost, lack of need/deliberate non-adherence, and unintentional non-adherence. Total scores range from 16 to 80, with higher scores indicating worse adherence.

Trial sites (1)

Facility	City	Region	Status
Sun Yat-sen Memorial Hospital, Sun Yat-sen University	Gu'ang'zhou	Guangdong

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07543393 on ClinicalTrials.gov ↗ ← All trials in China