Clinical Outcomes After Non-curative Endoscopic Resection in Early Colorectal Cancer: A Multicenter Study

Condition(s) studied

Investigational drug(s) / intervention(s)

Additional Surgery: Additional surgical resection performed after non-curative endoscopic resection based on pathological risk factors and clinical indications.

Surveillance: Active surveillance with regular endoscopic and imaging follow-up without additional surgical intervention.

Study summary

This multicenter study aims to evaluate clinical outcomes and optimize management strategies in patients with early colorectal cancer who undergo non-curative endoscopic resection.

Patients with non-curative resection following endoscopic treatment will be enrolled across multiple centers and managed according to real-world clinical decisions, including additional surgery or surveillance. Baseline demographic, endoscopic, and pathological characteristics will be systematically collected.

The primary objective is to compare recurrence and survival outcomes between different management strategies. Secondary objectives include identifying prognostic factors associated with recurrence and developing a risk stratification model to guide individualized treatment decisions.

All participants will undergo standardized follow-up according to clinical guidelines. This study is expected to provide real-world evidence to refine risk assessment, reduce unnecessary surgery, and improve personalized management for patients with early colorectal cancer after non-curative endoscopic resection.

Eligibility

Primary outcome measure(s)

• Recurrence-Free Survival — Up to 2 years

Trial sites (3)

More Nanfang Hospital, Southern Medical University trials in China