HUMSCs Combined With Col I to Third-Degree Burn Wound

NCT07530003 · tracked via the Priya Life Science China tracker

Sponsor

The First Affiliated Hospital of Xinxiang Medical College

Phase

Phase 1/2

Started

2026-04-06

Last updated

2026-05-04

Condition(s) studied

Burn WoundsThird-Degree Burn Wounds

Investigational drug(s) / intervention(s)

HUMSCs combined with bovine type I collagenbovine type I collagenSterile blank dressing / Vaseline gauze

HUMSCs combined with bovine type I collagen: To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells combined with bovine type I collagen in the treatment of third-degree burn wounds

bovine type I collagen: To evaluate the safety and tolerability of bovine type I collagen in the treatment of third-degree burn wounds

Sterile blank dressing / Vaseline gauze: To evaluate the safety and tolerability of sterile blank dressing / vaseline gauze in the treatment of third-degree burn wounds.

Study summary

To evaluate the safety and tolerability of human umbilical cord mesenchymal stem cells combined with bovine type I collagen in the treatment of third-degree burn wounds.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * Aged 18-65 years, gender unrestricted * Confirmed third-degree burns, wound area 1%-5% TBSA * Admission within 72 hours after burn injury * Voluntarily signed informed consent * Able to cooperate and complete follow-up Exclusion Criteria: * Pregnant or lactating females * Severe immunodeficiency or autoimmune disease * History of malignant tumor, or coagulation dysfunction * Severe cardiac, hepatic, or renal insufficiency * Hypersensitivity to collagen or stem cell components * Uncontrollable severe wound infection * Participation in other clinical studies within the past 3 months * Inability to comply with follow-up

Primary outcome measure(s)

Re-epithelialization areas — Up to 6 month
Re-epithelialization will be determined by clinical evaluations and recorded by digital color photographs
Complete burn wound healing — Up to 12 month
Time (days) to complete re-epithelialization of burned skin. It will be based on clinical evaluations and digital color photographs

Trial sites (1)

Facility	City	Region	Status
The First Affiliated Hospital of Xinxiang Medical College	Xinxiang	Henan	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07530003 on ClinicalTrials.gov ↗ ← All trials in China