A Clinical Study to Evaluate the Efficacy and Safety of VG2025 in Intrahepatic Cholangiocarcinoma

Inclusion Criteria: 1. Signed written informed consent form. 2. Age 18 to 75 years (inclusive), male or female. 3. Histologically or cytologically confirmed advanced intrahepatic cholangiocarcinoma. 4. Eligible participants of childbearing participants(male and female) must agree to use a reliable method of contraception during the trial and for at least 90 days after dosing; females of childbearing potential must have a negative blood pregnancy test 7 days before enrollment. Exclusion Criteria: 1. Participants who have received other unlisted drugs clinical trial treatment 4 weeks before the first dose of the study drug. 2. Participants who underwent major organ surgery (excluding needle biopsy) or had significant trauma 4 weeks before the first dose of the study drug. 3. In the herpes simplex virus recurrence and infection period, and there are corresponding clinical manifestations, such as oral herpes labialis, herpetic keratitis, herpetic dermatitis, genital herpes and so on. 4. Other active uncontrolled infection. 5. Known alcohol or drug dependence. 6. Participants with mental disorders or poor compliance. 7. Women who are pregnant or breastfeeding. 8. Participants in the opinion of the investigator are not suitable for this clinical study due to other serious systemic diseases or other reasons.