Using air purifiers with high-efficiency particulate air (HEPA) and carbon filtersUsing air purifiers with non-functional filtration system
Using air purifiers with high-efficiency particulate air (HEPA) and carbon filters: Participants in the intervention arm will receive active air purifiers, which will be installed in their bedroom and the room where they spend the most time at home. The devices will operate continuously for the entire intervention period.
Using air purifiers with non-functional filtration system: Participants in the intervention arm will receive sham air purifiers, which will be installed in their bedroom and the room where they spend the most time at home. The devices will operate continuously for the entire intervention period.
Study summary
This randomized, double-blind, parallel-controlled trial aims to evaluate the effects of an indoor air purifier intervention on respiratory health in patients with Chronic Obstructive Pulmonary Disease (COPD).
Eligibility
Sex
ALL
Min age
50 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Age between 50 and 80 years old
* Physician diagnosis of COPD
* Living in Shanghai during the intervention period
* Subjects who have no plans to change homes during the intervention period
* Non-smokers and former smokers
Exclusion Criteria:
* Subjects living in a location other than home
* Subjects with a history of alcohol abuse
* Subjects with other chronic lung diseases, such as active tuberculosis, pulmonary fibrosis, cystic fibrosis, or alpha-1 antitrypsin deficiency
* Subjects with a history of thoracic surgery
* Subjects with a history of malignant tumors, such as lung cancer, liver cancer, or gastric cancer
* Subjects with diagnosed chronic hepatic or renal insufficiency, such as liver cirrhosis, chronic viral hepatitis, or autoimmune liver disease
* Subjects with acute myocardial infarction or unstable arrhythmia diagnosed within the past 6 weeks
* Subjects currently participating in other interventional studies
Primary outcome measure(s)
Changes in the percentage of low attenuation area at -950 Hounsfield units (%LAA-950) — Baseline and after the completion of the intervention period (12 months anticipated) %LAA-950 was defined as the percentage of voxels with attenuation lower than -950 Hounsfield units. A higher percentage reflects more severe emphysematous destruction of lung tissue.
Changes of wall area percentage (WA%) — Baseline and after the completion of the intervention period (12 months anticipated) Airway wall thickness was calculated as the mean percentage of wall area (WA%) of prespecified segmental and subsegmental bronchi from each lung lobe.
Changes of forced expiratory volume in 1 s (FEV1) — Baseline, and at the 1st, 3rd, 6th, and 12th months (12 months anticipated) The pulmonary function measures are performed by a professional medical device. Before the pulmonary function test, subjects practice several times with the guidance of professional staff. During the examination, each subject is in a sitting position and clamps the nose clip, and repeats the test, with the best result as the criterion.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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