Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration

Condition(s) studied

Investigational drug(s) / intervention(s)

Transcranial magnetic stimulation targeting occipital visual cortex: Transcranial magnetic stimulation targeting occipital visual cortex

Sham stimulation: identical procedure using a sham coil without effective magnetic field output

Study summary

The goal of this clinical trial is to learn if transcranial magnetic stimulation (TMS) works to restore vision in adults with severe retinal degeneration. It will also learn about the safety of TMS treatment. The main questions it aims to answer are:

1. Does TMS treatment improve the visual function of participants?
2. What medical problems do participants have when receiving TMS treatment? Researchers will compare TMS treatment to a sham stimulation (identical procedures using a sham coil without effective magnetic field output) to see if TMS treatment works to restore their vision.

Participants will:

UndergoTMS treatment to a sham stimulation for consecutive 5 days Visit the clinic at 5 days, 4 weeks, 3 months, 6 months, 12 months after start of the treatment for checkups and tests

Eligibility

Primary outcome measure(s)

• Best-corrected visual acuity (BCVA) change — Baseline and 3 months
  the change of best-corrected visual acuity (BCVA, measured by internationally standard EDTRS chart) between 3 months after the end of treatment and baseline

Trial sites (4)

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