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Clinical Trials in China / NCT07399444
Starting soon Phase EARLY_PHASE1

A Clinical Study to Evaluate LVIVO-TaVec400 for the Treatment of Relapsed/Refractory Multiple Myeloma(LB2505-0001)

NCT07399444 · tracked via the Priya Life Science China tracker
Sponsor
Institute of Hematology & Blood Diseases Hospital, China
Phase
Phase EARLY_PHASE1
Started
2026-01-10
Last updated
2026-02-10

Condition(s) studied

Multiple Myeloma (MM)

Investigational drug(s) / intervention(s)

LVIVO-TaVec400 product

LVIVO-TaVec400 product: Prior to infusion of the LVIVO-TaVec400 product, subjects will receive bridging therapy if needed.

Study summary

This is a prospective, single-arm, open-label dose-escalation clinical study to evaluate LVIVO-TaVec400 in the treatment of relapsed/refractory multiple myeloma.

Eligibility

Sex
ALL
Min age
18 Years
Max age
Healthy volunteers
No
Inclusion Criteria: 1. Subjects voluntarily participate in clinical studies; Fully informed of this study and signed informed consent; Informed consent form must be obtained prior to initiation of any study-related tests or procedures that are not part of the standard treatment for the subject's disease; Good compliance and cooperation with follow-up. 2. Age ≥ 18 years. 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. 4. Has measurable lesions 5. Relapsed and/or refractory multiple myeloma 6. Life expectancy≥ 3 months 7. Clinical laboratory values meet screening visit criteria 8. Adequate organ function. Exclusion Criteria: 1. Prior antitumor therapy with insufficient washout period ; 2. Patients who are positive for hepatitis B surface antigen (HBsAg), hepatitis B virus deoxyribonucleic acid (HBV DNA), hepatitis C antibody (HCV-Ab), hepatitis C virus ribonucleic acid (HCV RNA), and human immunodeficiency virus antibody (HIV-Ab). 3. Those who have experienced life-threatening allergic reactions, hypersensitivity reactions or intolerances to the excipients and related additives of the investigational drug; or those with a previous history of severe allergic reactions (such as hypersensitivity reactions, or those for whom the investigator assesses the need to use glucocorticoids to prevent severe immune-related reactions such as allergic reactions). 4. Any condition deemed by the investigator as rendering the subject unsuitable for participation in this study. 5. Also enrolled in other clinical studies.

Primary outcome measure(s)

Trial sites (6)

FacilityCityRegionStatus
Henan Cancer Hospital Zhengzhou Henan
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei
The Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu
The First Affiliated Hospital of Nanchang University Nanchang Jiangxi
Beijing GoBroad Boren Hospital Beijing China
Institute of Hematology & Blood Diseases Hospital Tianjin China

More Institute of Hematology & Blood Diseases Hospital, China trials in China

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07399444 on ClinicalTrials.gov ↗ ← All trials in China