Steroid nasal drops combined with olfactory trainingPlacebo nasal drops combined with olfactory training
Steroid nasal drops combined with olfactory training: The intervention consists of two components: steroid nasal drops and modified olfactory training.
Placebo nasal drops combined with olfactory training: The intervention consists of two components: normal saline nasal drops and modified olfactory training.
Study summary
This study aims to evaluate the effectiveness of hormone nasal drops in the olfactory cleft combined with olfactory training for treating postinfectious olfactory dysfunction (PIOD). The main questions this clinical trial seeks to answer are:
Can the combination of hormone nasal drops and olfactory training improve smell function better than olfactory training alone in PIOD patients? How does this combined treatment work?
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
1. Prospective enrollment of otolaryngology clinic patients aged 18-65 years with olfactory dysfunction. Diagnosis of post-infectious olfactory dysfunction (PIOD) will be based on the PPOD 2023 criteria. Participants must demonstrate olfactory impairment via Sniffin' Sticks testing, with TDI scores (sum of Threshold, Discrimination, and Identification) meeting: (1) Hyposmia: 16 \< TDI \< 30.75; (2) Anosmia: TDI ≤ 15.
2. Willingness to participate and signed informed consent.
Exclusion Criteria:
1. Use of systemic corticosteroids within 4 weeks or intranasal steroids within 2 weeks prior to enrollment.
2. Severe nasal septum deviation, nasal tumors, acute upper respiratory infections, or uncontrolled allergic rhinitis.
3. History of functional endoscopic sinus surgery or other nasal procedures within 12 months.
4. Severe cardiovascular disease, hepatic/renal insufficiency, uncontrolled diabetes, or immune system disorders.
5. Current or planned pregnancy.
6. Investigator-determined inability to comply with study requirements (e.g., memory/behavioral disorders, depression, heavy alcohol use, prior non-compliance).
Primary outcome measure(s)
The Sniffin' Sticks test — Baseline, 1 week, 4 weeks, 8 weeks, and 12 weeks after the initiation of treatment. A clinically significant olfactory improvement as measured by Sniffin' Sticks threshold, discrimination, and identification(TDI)
Trial sites (1)
Facility
City
Region
Status
Dawei Wu
Beijing
Beijing Municipality
More Peking University Third Hospital trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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