This observational study aims to investigate the characteristics of gut microbiota and their associations with immune and nutritional indicators in children with different respiratory health statuses. A total of 120 children will be enrolled and categorized into four groups: children with Mycoplasma pneumoniae pneumonia (MPP), children with acute respiratory tract infections without Mycoplasma pneumoniae (NMP), children with recurrent respiratory tract infections (RRTIs), and healthy controls. By comparing gut microbiota composition and diversity, as well as immune- and nutrition-related indicators across groups, this study seeks to clarify the potential role of intestinal dysbiosis and host immune-nutritional interactions in the pathogenesis and clinical manifestations of pediatric respiratory tract infections.
Eligibility
Sex
ALL
Min age
3 Years
Max age
14 Years
Healthy volunteers
Accepted
Inclusion Criteria
1. Aged 3-14 years;
2. Good compliance and complete clinical data;
3. Guardians are informed and sign written consent;
4. MPP group: meets diagnostic criteria of Guidelines for Diagnosis and Treatment of Mycoplasma Pneumoniae Pneumonia in Children (2023 Edition);
5. NMP group: acute respiratory tract infection with negative MP-DNA/RNA;
6. RRTIs group: meets diagnostic criteria of Clinical Diagnosis and Treatment Pathway for Recurrent Respiratory Tract Infections in Children (2022 Edition);
7. Healthy controls: no respiratory infection history within the past month.
Exclusion Criteria
1. Other infectious diseases (e.g., measles, pertussis, tuberculosis);
2. Congenital heart disease, immunodeficiency, or major organ dysfunction;
3. Use of antibiotics, probiotics, immunomodulators, hormones, or microecological preparations within the past 15-30 days;
4. Unqualified biological samples or incomplete laboratory data.
Primary outcome measure(s)
Microbiota profiles of fecal samples in all children cohorts as assessed via metagenomics sequencing — Day-1 Differences in microbiota abundance in fecal sample of children with respiratory diseases compared to healthy cohort
Trial sites (2)
Facility
City
Region
Status
The 940th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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