The Analgesic Efficacy and Safety of Baclofen in Patients With Herpes Zoster

Condition(s) studied

Investigational drug(s) / intervention(s)

Baclofen combined conventional therapy: In the baclofen combined conventional therapy group, baclofen will be initiated at 15 mg daily. Then, based on the patient's response, the single dose can be gradually increased by 5mg each time, with a three-day interval. The maximum recommended dose is 30\~75mg daily. In addition, the group will contain conventional treatment for HZ, except baclofen, including NSAIDs, opioids, antiviral drugs and so on.

Conventional therapy: In the conventional therapy group, treatments will include NSAIDs, opioids, antiviral drugs and so on.

Study summary

Herpes zoster (HZ) is characterized by a painful dermatomal rash and significantly affects quality of life, with acute pain increasing the risk of postherpetic neuralgia. Although early antiviral therapy limits viral replication, its analgesic effect is insufficient, and many patients experience inadequate relief despite stepwise use of non-opioids and opioids. Recent attention has focused on the potential role of muscle relaxant, which can relieve skeletal muscle spasms and associated pain in acute musculoskeletal conditions. Therefore, investigators hypothesize that baclofen may effectively reduce the severity of HZ pain without significantly increasing adverse events.

Eligibility

Primary outcome measure(s)

• the average numeric rating scale score over the past 24 hours, rated each morning upon awakening and average over 7 days. — At week 4 after experimental drug medication
  The numeric rating scale (NRS) score is a way to quantify the degree of subjective feelings such as pain using numbers. Generally, 0 represents no pain, and 10 represents the most severe pain. A higher score indicates more severe pain.

Trial sites (1)

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