A Clinical Study to Evaluate the Efficacy and Safety of D-2570 in the Treatment of Moderate to Severe Plaque Psoriasis
Condition(s) studied
Investigational drug(s) / intervention(s)
D-2570 Tablet: D-2570 is a novel inhibitor targeting the TYK2 pseudokinase domain
BMS-986165 Tablet: BMS-986165 is a novel inhibitor targeting TYK2
Placebo: A placebo refers to a tablet that has no therapeutic effect on medication
Study summary
This study is a randomized, double-blind, placebo- and active-controlled multicenter clinical trial involving patients with moderate to severe plaque psoriasis.
Safety and efficacy assessments will be conducted during the scheduled study visits throughout the trial. After completing the respective treatment, all subjects will undergo a safety follow-up. Both the investigators and subjects will remain blinded throughout the entire treatment period.
During the study, subjects are required to provide blood samples for pharmacokinetic (PK) and pharmacodynamic (PD) analyses at the time points specified in the trial protocol.
Eligibility
Primary outcome measure(s)
- To evaluate the efficacy of different doses of D-2570 compared with placebo in the treatment of patients with moderate to severe plaque psoriasis — Treatment for 16 weeks after enrollment
Psoriasis Area and Severity Index (PASI) - To evaluate the efficacy of different doses of D-2570 compared with placebo in the treatment of patients with moderate to severe plaque psoriasis — Treatment for 16 weeks after enrollment
Physician Global Assessment (PGA) - To evaluate the efficacy of different doses of D-2570 compared with placebo in the treatment of patients with moderate to severe plaque psoriasis — Treatment for 16 weeks after enrollment
Dermatology Life Quality Index (DLQI)
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Shanghai Skin Disease Hospital | Shanghai | Shanghai Municipality | Recruiting |
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Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07326813 on ClinicalTrials.gov ↗ ← All trials in China