This study is a prospective observational study. The study will explore the correlation between advanced glycation end products and gastric motility disorder in diabetic gastroparesis（DGP) through the collection of blood and gastric tissue samples and relevant data of patients with DGP and control group patients without diabetes history and gastroparesis symptoms.
Eligibility
Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria for diabetes gastroparesis group:
* Meet the diagnostic criteria for diabetes
* Presence of symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
* Age range from 18 to 75 years old
* Voluntarily participate and sign an informed consent form
Inclusion Criteria for control group:
* No history of diabetes
* No symptoms (see assessment of Gastroparesis Cardinal Symptom Index)
* Age range from 18 to 75 years old
* Voluntarily participate and sign an informed consent form
Exclusion Criteria for diabetes gastroparesis group and control group:
* Currently taking prokinetic drugs, anticholinergic drugs, and dopamine drugs that may affect gastric motility
* Has a history of gastrointestinal surgery
* Pregnant or preparing to conceive
* There are neurological disorders such as Parkinson's disease that affect gastrointestinal function
* Outlet obstruction caused by organic lesions in the pylorus
Primary outcome measure(s)
Gastroparesis Cardinal Symptom Index (GCSI) score — The day when the subjects were enrolled The Gastroparesis Cardinal Symptom Index (GCSI) is a patient-reported outcome measure used to assess the severity of gastroparesis symptoms. It consists of nine items grouped into three subscales: postprandial fullness/early satiety, nausea/vomiting, and bloating. Patients rate the severity of each symptom on a scale from 0 (no symptom) to 5 (very severe). The GCSI score is calculated as an average score of all three symptom categories. It is a reliable and valid tool for evaluating symptom severity and treatment effectiveness in clinical trials and other studies
Trial sites (1)
Facility
City
Region
Status
Northern Jiangsu People's Hospital
Yangzhou
Jiangsu
Recruiting
More Northern Jiangsu People's Hospital trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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