High-Flow Nasal Cannula for Preventing Hypoxia During Sedated Endoscopy in High-Risk Obstructive Sleep Apnea Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

High-flow nasal cannula Group: Using High-flow nasal cannula oxygenation

Regular Nasal Cannula: Using regular nasal cannula for oxygenation

Study summary

Hypoxia represents the most frequent adverse event during propofol-sedated gastrointestinal endoscopy. The STOP-BANG questionnaire serves as a widely adopted, straightforward tool for screening obstructive sleep apnea (OSA) risk, with a score ≥5 identifying high-risk OSA patients who are particularly susceptible to hypoxia under sedation. Although preliminary research from our team suggests that High-Flow Nasal Cannula (HFNC) may lower the incidence of hypoxemia, evidence remains limited and inconsistent in studies specifically targeting high-risk OSA populations. Therefore, this multicenter randomized controlled trial aims to evaluate whether HFNC can effectively reduce the occurrence of hypoxia during sedated gastrointestinal endoscopy in patients identified as high-risk for OSA.

Eligibility

Primary outcome measure(s)

• The incidence of hypoxia — Patients will be followed for the duration of hospital stay, an expected average about 2 hours
  75% ≤ SpO2 \< 90% for \<60 s

Trial sites (3)

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