Aortic no-touch coronary artery bypass grafting (RIMA-SVG)Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)
Aortic no-touch coronary artery bypass grafting (RIMA-SVG): Ascending aortic no-touch CABG with saphenous vein graft (SVG) anastomosed to the right internal mammary artery (RIMA)
Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG): Off-pump CABG with proximal saphenous vein graft (SVG) anastomoses constructed on the ascending aorta using a partial-occlusion (side-biting) clamp.
Study summary
To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden. Specifically:
This multicenter, randomized controlled clinical trial will evaluate the benefits of a novel aortic no-touch technique in reducing perioperative silent brain infarction(SBI) among patients undergoing surgical treatment for coronary artery disease. The findings are expected to provide a safe and effective myocardial revascularization strategy for individuals at high risk of cerebral ischemia.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Adult patients (\>18 years old) with multivessel coronary artery disease who are scheduled to undergo isolated off-pump coronary artery bypass grafting and who provide informed consent to participate in this study.
Exclusion Criteria:
* Indications for cardiopulmonary bypass surgery (or no contraindications to on-pump surgery);
* Great saphenous vein is unsuitable for use as a graft conduit;
* Subclavian artery stenosis or occlusion, or any contraindication to the use of the internal mammary artery as a graft conduit;
* History of previous cardiac surgery;
* Emergency surgery;
* Inability to apply an aortic clamp due to severe ascending aortic calcification;
* Expected inability to tolerate MRI or contraindications to MRI (e.g., known intolerance to MRI, an implanted permanent pacemaker, or an anticipated need for permanent pacemaker implantation);
* Inability to complete neurocognitive assessment due to language barriers or visual/hearing impairment.
Primary outcome measure(s)
Saphenous vein graft (SVG) occlusion rate — 1 year after surgery Assessed by coronary computed tomography angiography (CCTA)
New-onset clinical stroke and silent brain infarction (SBI) — 7 ± 3 days after surgery Clinical stroke and SBI assessed at 7 ± 3 days postoperatively; SBI assessed by brain magnetic resonance imaging (MRI).
Trial sites (4)
Facility
City
Region
Status
Fuwai Hospital Chinese Academy of Medical Sciences
Beijing
China
Recruiting
Peking University First Hospita
Beijing
China
Not Yet Recruiting
Qingdao Cardiovascular Hospital
Qingdao
China
Not Yet Recruiting
Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
Shenzhen
China
Not Yet Recruiting
More China National Center for Cardiovascular Diseases trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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